Topics in our Analytical Clinical Biochemistry Notes PDF
In these “Analytical Clinical BiochemistryNotes PDF”, you will study the biochemically significant features of the proteins, enzymes, nucleic acids and lipids, using suitable examples. This includes classification, properties and biological importance of biomolecules. The course provides an overview of drug receptor interaction and Structure Activity Relation (SAR) studies. It will introduce the students to the concept of genetic code and concept of heredity. Key emphasis is placed on understanding the basic principles that govern the biological functions of biomolecules.
The topics we will cover will be taken from the following list:
Metabolism: Biological importance of carbohydrates and proteins, Introduction to metabolism (catabolism, anabolism), ATP: the universal currency of cellular energy, outline of catabolic pathways of fats, proteins and carbohydrate-glycolysis, alcoholic and lactic acid fgermentation, Krebs cycle.
Enzymes: Nomenclature, classification, Characterisation, Mechanism of enzyme action, factors affecting enzyme action, Coenzymes and cofactors and their role in biological reactions, Specificity of enzyme action (Including stereospecificity), Enzyme inhibitors and their importance, Introduction to biocatalysis: Importance in ―green chemistry and chemical industry. Drug action-receptor theory. Structure – activity relationships of drug molecules, binding role of –OH group, -NH2 group, double bond and aromatic ring.
Lipids: Classification. Biological importance of triglycerides and phosphoglycerides and cholesterol; Liposomes and their biological functions and underlying applications, Lipoproteins. Properties, functions and biochemical functions of steroid hormones and peptide hormones.
Nucleic Acids: Components of nucleic acids: adenine, guanine, thymine and cytosine (structure only), other components of nucleic acids, nucleosides and nucleotides (numbering), structure of DNA (Watson-Crick model) and RNA (types of RNA), genetic code, biological roles of DNA and RNA: replication, transcription and translation.
Biochemistry of disease: A diagnostic approach by blood/ urine analysis, Blood: composition and functions of blood, blood coagulation. Blood collection and preservation of samples, Anaemia, Urine: Collection and preservation of samples. Formation of urine. Composition and estimation of constituents of normal and pathological urine. Regulation, estimation and interpretation of data for blood sugar, urea, creatinine, cholesterol and bilirubin.
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