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Pharmaceutical Chemistry Notes

Topics in our Pharmaceutical Chemistry Notes PDF

In these “Pharmaceutical Chemistry Notes PDF”, you will study the basic understanding of drugs discovery, design, development and their side effects. The course will cover synthesis of major drug classes including-analgesics, antipyretics, anti- inflammatory agents, antibacterial and antifungal agents, antiviral agents, central nervous system agents and drugs for HIV–AIDS. An overview of fermentation process and production of certain dietary supplements and certain common antibiotics.

The topics we will cover will be taken from the following list:

Introduction: Drug discovery, design and development: Sources of drugs: biological, marine, minerals and plant tissue culture, physio-chemical aspects (optical, geometric and bioisosterism) of drug molecules and biological action, drug receptor interaction, basic retro-synthetic approach for development of drug. Cause of side effect of drugs like ibuprofen, cetirizine, thalidomide. Difference between drug and poison.

Drugs and Pharmaceuticals: Study of pharmaceutical aids like talc, diatomite, kaolin, bentomite, gelatin and natural colours Synthesis of the representative drugs of the following classes: analgesics agents, antipyretic agents, anti-inflammatory agents (Aspirin); antibacterial and antifungal agents (Sulphonamides; Sulphanethoxazol, Sulphacetamide, Trimethoprim); antiviral agents (Acyclovir), central nervous system agents (Phenobarbital, Diazepam),Cardiovascular (Glyceryl trinitrate), antilaprosy (Dapsone), HIV-AIDS related drugs (AZT- Zidovudine).

Fermentation: Aerobic and anaerobic fermentation. Production of (i) Ethyl alcohol and citric acid, (ii) Antibiotics; Penicillin, Cephalosporin, Chloromycetin and Streptomycin, (iii) Lysine, Glutamic acid, Vitamin B2, Vitamin B12 and Vitamin C.


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